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Its presence in drug-related deaths rose from 0.3% to 6.7% between 2015 and 2020, according to a 2022 report published in Drug and Alcohol Dependence. That rate was more than 10% in Connecticut.

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Gregory House is the fictional protagonist of the American medical drama series House.Created by David Shore and portrayed by English actor Hugh Laurie, he leads a team of diagnosticians and is the Head of Diagnostic Medicine at the fictional Princeton-Plainsboro Teaching Hospital in Princeton, New Jersey. House's character has been described as a misanthrope, cynic, narcissist, and curmudgeon.

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Results: In total, 2247 opioid-naive lower extremity amputees were identified. An estimated 54.7% of patients utilized opioids in the perioperative period, and 44.6% were found to have prolonged opioid use. Younger age (ages 40-50 versus older), history of chronic pain, migraines, lower back pain, Charlson Comorbidity Index greater than 1.